پلی میکسین B سولفات سالت p1004 سیگما

پلی میکسین B سولفات سالت p1004 سیگما Polymyxin B sulfate salt p1004 sigma P1004SIGMA-ALDRICH Polymyxin B sulfate salt Properties Related Categories Antibacterial,Antibiotics,Antibiotics A to Z,Antibiotics N-S,Antibiotics by Application, More... solubility H2O: soluble50mg/mL Mode of action cell membrane | interferes cell membrane | interferes antibiotic activity spectrum Gram-negative bacteria fungi storage temp. 2-8C Description Biochem/physiol Actions Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli, includingE. Coliand on most fungi and gram-positive bacteria. Caution As supplied, the product should be stored at 2-8C in the dark. No change was observed in retained samples after three years of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8C. They are stable at 37C for 5 days. Packaging 1000000, 5000000, 10000000, 25000000, 50000000 units in poly bottle Preparation Note Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol. Application Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation ofBacilus polymyxa.It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains ofPseudomonas aeruginosa.It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. Other Notes Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Safety Information Personal Protective Equipment dust mask type N95 (US),Eyeshields,Gloves RIDADR NONH for all modes of transport WGK Germany 3 RTECS TR1150000